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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4518 | Licochalcone D | ERK , NF-κB | |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... | |||
TD0099 | Malachite green oxalate | Apoptosis , Others , IκB/IKK , NF-κB | |
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
T22021 | ACHP | IKK-2 Inhibitor VIII | IκB/IKK |
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression thro... | |||
T2856 | (-)-Epicatechin | L-Epicatechin,Epicatechin,(-)-Epicatechol | Ferroptosis , COX , Endogenous Metabolite |
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. | |||
T4237 | Rubiadin-1-methyl ether | Rubiadin 1-methyl ether | Anti-infection , NF-κB |
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu... | |||
T11598 | IAXO-102 | TLR | |
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin... | |||
TN1786 | Isomerazin | Isomeranzin | ERK , NF-κB , AChE |
Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway. | |||
T1930 | JSH-23 | NF-κB | |
JSH-23, an NF-κB inhibitor(IC50= 7.1 μM), suppresses the transcriptional activity. | |||
T6661 | SC75741 | Influenza Virus , NF-κB | |
SC75741 is a potent P65 inhibitor with IC50 of 200 nM | |||
T6S0117 | Avicularin | Fenicularin | ERK |
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... | |||
T3772 | Maslinic acid | 2α-Hydroxyoleanoic Acid,2α-Hydroxyoleanolic acid,Crategolic acid | NF-κB , HIV Protease , DNA/RNA Synthesis , Antibacterial |
Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor. | |||
T4S1469 | Cucurbitacin IIb | Apoptosis , Others | |
1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-i... | |||
T3012 | Mangiferin | Alpizarin,Chinomin,Hedysarid | Apoptosis , Others , NF-κB , Nrf2 |
Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L. | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T6454 | CORM-3 | CORM3 | Others , NF-κB , NOD-like Receptor (NLR) |
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. | |||
T2913 | Schisantherin A | Schisanwilsonin H,Gomisin-C,Wuweizi ester-A,Schizantherin-A,Arisanschinin K | NF-κB |
Schisantherin A (Wuweizi ester-A) is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent. | |||
T6S1538 | Neochlorogenic acid | trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid | TNF , NF-κB , COX , Antibacterial , Interleukin |
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions. | |||
T3753 | Sinapinic Acid | Sinapic acid,Synapoic acid | Apoptosis , RAAS , Reactive Oxygen Species , HDAC |
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap... | |||
T6S1487 | Ginsenoside Rg5 | NF-κB , COX , IGF-1R | |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ... |